Prognostic Impact of Resection Margin Distance in Patients with Completely Resected Stage I NSCLC after Lobectomy
Presented During:
Sunday, May 4, 2025: 9:00AM - 4:00PM
Seattle Convention Center | Summit
Posted Room Name:
Poster Area, Exhibit Hall
Abstract No:
P0187
Submission Type:
Abstract Submission
Authors:
Shia Kim (1), Geun Dong Lee (2), Sehoon Choi (3), Hyeong Ryul Kim (4), Yong-Hee Kim (4), Dong Kwan Kim (4), Seung-Il Park (4), Jae Kwang Yun (5)
Institutions:
(1) Asan Medical Center, Seoul, South Korea, (2) Asan Medical Center, Seoul, Songpa-gu, (3) Asan Medical Center, Seoul, Seoul, (4) Asan Medical Center, Songpa-gu, Seoul, (5) Asan Medical Center, Seoul, NA
Submitting Author:
Shia Kim
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Asan Medical Center
Asan Medical Center
Co-Author(s):
Geun Dong Lee
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Asan Medical Center
Asan Medical Center
Sehoon Choi
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Asan Medical Center
Asan Medical Center
Hyeong Ryul Kim
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Asan Medical Center
Asan Medical Center
Yong-Hee Kim
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Asan Medical Center
Asan Medical Center
Dong Kwan Kim
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Asan Medical Center
Asan Medical Center
Seung-Il Park
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Asan Medical Center
Asan Medical Center
Jae Kwang Yun
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Asan Medical Center
Asan Medical Center
Presenting Author:
Shia Kim
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Asan Medical Center
Asan Medical Center
Abstract:
Objective: Unlike sublobar resection, the prognostic impact of margin distance has not been fully evaluated in patients who underwent lobectomy for stage I non-small cell lung cancer (NSCLC). We investigated the prognostic value of the resection margin distance and determine the cutoff value in these patients.
Methods: Between 2011 and 2021, data of patients with completely resected stage I NSCLC after lobectomy were analyzed. The margin distance and ratio were defined as the distance from the primary tumor to the bronchial resection margin and the margin distance divided tumor size. The optimal cutoff value was selected using a maximally selected log-rank statistic.
Results: A total of 3,727 patients were included as the final cohort, of whom 211 (5.7%), 1202 (32.3%), 1175 (31.5%), and 1139 (30.6%) patients were in stages IA1, IA2, IA3, and IB, respectively. The most optimal cutoffs for the margin distance and the margin ratio for cancer recurrence within 5 years were 25mm and 1.5, respectively. In the multivariable analysis, the margin distance (<25mm vs. ≥25mm; hazard ratio [HR], 1.34; 95% confidence interval [CI], 1.11–1.61; p = 0.002) and the margin ratio (<1.5 vs. ≥1.5; HR, 1.40; 95% CI, 1.14 to 1.71; p <0.001) were significant factors for recurrence-free survival in patients after lobectomy for stage I NSCLC.
Conclusion: The margin distance has a significant prognostic impact in patients who underwent lobectomy for stage I NSCLC. Cutoff values of margin distance ≥25mm and margin ratio ≥1.5 could help clinicians enact proper treatment strategies and surveillance for these patients.
Methods: Between 2011 and 2021, data of patients with completely resected stage I NSCLC after lobectomy were analyzed. The margin distance and ratio were defined as the distance from the primary tumor to the bronchial resection margin and the margin distance divided tumor size. The optimal cutoff value was selected using a maximally selected log-rank statistic.
Results: A total of 3,727 patients were included as the final cohort, of whom 211 (5.7%), 1202 (32.3%), 1175 (31.5%), and 1139 (30.6%) patients were in stages IA1, IA2, IA3, and IB, respectively. The most optimal cutoffs for the margin distance and the margin ratio for cancer recurrence within 5 years were 25mm and 1.5, respectively. In the multivariable analysis, the margin distance (<25mm vs. ≥25mm; hazard ratio [HR], 1.34; 95% confidence interval [CI], 1.11–1.61; p = 0.002) and the margin ratio (<1.5 vs. ≥1.5; HR, 1.40; 95% CI, 1.14 to 1.71; p <0.001) were significant factors for recurrence-free survival in patients after lobectomy for stage I NSCLC.
Conclusion: The margin distance has a significant prognostic impact in patients who underwent lobectomy for stage I NSCLC. Cutoff values of margin distance ≥25mm and margin ratio ≥1.5 could help clinicians enact proper treatment strategies and surveillance for these patients.
THORACIC:
Lung Cancer
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