Size and Morphological Differences of Thoracic Cage in Marfan vs Non-Marfan patients
Presented During:
Thursday, April 25, 2024: 5:38PM - 7:00PM
Sheraton Times Square
Posted Room Name:
Central Park
Abstract No:
P0309
Submission Type:
Abstract Submission
Authors:
Yuki Kuroda (1), Takehiko Matsuo (1), Hiroaki Osada (1), Masahide Kawatou (1), Takahide Takeda (1), Fumie Takai (1), Kazuhiro Takatoku (1), Hiromasa Kira (1), Yasuyuki Fujimoto (1), Haruka Fujimoto (1), Kazuyoshi Kanno (1), Tadashi Ikeda (1), Kenji Minatoya (1)
Institutions:
(1) Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Submitting Author:
Yuki Kuroda
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Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University
Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University
Co-Author(s):
Takehiko Matsuo
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Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University
Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University
Hiroaki Osada
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Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University
Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University
Masahide Kawatou
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Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University
Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University
Takahide Takeda
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Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University
Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University
Fumie Takai
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Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University
Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University
Kazuhiro Takatoku
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Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University
Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University
Hiromasa Kira
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Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University
Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University
Yasuyuki Fujimoto
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Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University
Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University
Haruka Fujimoto
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Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University
Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University
Kazuyoshi Kanno
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Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University
Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University
Tadashi Ikeda
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Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University
Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University
*Kenji Minatoya
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Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University
Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University
Presenting Author:
Yuki Kuroda
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Kokura Memorial Hospital
Kokura Memorial Hospital
Abstract:
Objectives: Understanding thoracic cage morphology is essential for determining the optimal surgical incisions and approaches for thoracic aortic surgeries. We aimed to describe the size and morphological differences of the thoracic cage between Marfan and non-Marfan patients.
Methods: In this single-center retrospective cohort study, 58 Marfan patients and 1,535 non-Marfan patients diagnosed with aortic diseases were listed. Among these, 47 patients from each group were selected after exact matching to control for differences in sex and age categories. We compared physical data and computed tomography measurements of the thoracic cage between the two groups. Linear regression models were applied to estimate the effect size for Marfan syndrome patients in comparison to those without Marfan syndrome. The adjusted effect size was estimated using multiple linear regression models that accounted for sex, age, and body surface area.
Results: The Marfan group exhibited significantly greater height (Marfan: 177.1 ± 10.7 cm vs Non-Marfan: 166.3 ± 12.1 cm; P<0.001) and a significantly lower body mass index than the Non-Marfan group (Marfan: 22.3 ± 3.4 vs Non-Marfan: 20.0 ± 3.6; P=0.002). Angles between the ribs and the craniocaudal axis were significantly smaller in the Marfan group than in the non-Marfan group (45.0° vs 55.4° for the 4th rib; 42.2° vs 51.3° for the 5th rib; 39.7° vs 49.3° for the 6th rib; all P<0.001). At the level of the aortic valve, the adjusted analysis showed the Marfan group had significantly smaller anteroposterior distance, sternum-vertebra distance, transverse distance, and thoracic cavity area in comparison to the Non-Marfan group (Table). Furthermore, the angles between the ribs and the craniocaudal axis were significantly smaller in the Marfan group than in the Non-Marfan group in both crude and adjusted analyses. The angles between the ribs and the craniocaudal axis showed a mild correlation with the anteroposterior distance and the sternum-vertebra distance at the level of the aortic arch (R=0.22-0.34; all P<0.05), and a moderate correlation with those at the level of the aortic valve (R=0.46-0.54; all P<0.001).
Conclusions: Our findings implicate that patients with Marfan syndrome exhibit a flatter chest wall than those without Marfan syndrome. Better results may be obtained if these morphological differences are taken into account in the surgical strategy.
Methods: In this single-center retrospective cohort study, 58 Marfan patients and 1,535 non-Marfan patients diagnosed with aortic diseases were listed. Among these, 47 patients from each group were selected after exact matching to control for differences in sex and age categories. We compared physical data and computed tomography measurements of the thoracic cage between the two groups. Linear regression models were applied to estimate the effect size for Marfan syndrome patients in comparison to those without Marfan syndrome. The adjusted effect size was estimated using multiple linear regression models that accounted for sex, age, and body surface area.
Results: The Marfan group exhibited significantly greater height (Marfan: 177.1 ± 10.7 cm vs Non-Marfan: 166.3 ± 12.1 cm; P<0.001) and a significantly lower body mass index than the Non-Marfan group (Marfan: 22.3 ± 3.4 vs Non-Marfan: 20.0 ± 3.6; P=0.002). Angles between the ribs and the craniocaudal axis were significantly smaller in the Marfan group than in the non-Marfan group (45.0° vs 55.4° for the 4th rib; 42.2° vs 51.3° for the 5th rib; 39.7° vs 49.3° for the 6th rib; all P<0.001). At the level of the aortic valve, the adjusted analysis showed the Marfan group had significantly smaller anteroposterior distance, sternum-vertebra distance, transverse distance, and thoracic cavity area in comparison to the Non-Marfan group (Table). Furthermore, the angles between the ribs and the craniocaudal axis were significantly smaller in the Marfan group than in the Non-Marfan group in both crude and adjusted analyses. The angles between the ribs and the craniocaudal axis showed a mild correlation with the anteroposterior distance and the sternum-vertebra distance at the level of the aortic arch (R=0.22-0.34; all P<0.05), and a moderate correlation with those at the level of the aortic valve (R=0.46-0.54; all P<0.001).
Conclusions: Our findings implicate that patients with Marfan syndrome exhibit a flatter chest wall than those without Marfan syndrome. Better results may be obtained if these morphological differences are taken into account in the surgical strategy.
Aortic Symposium:
Descending/Thoracoabdominal Aorta
Image or Table
