Preoperative Cardiac Troponin I Predicts Early Outcomes in Surgery for Acute Type A Aortic Dissection
Presented During:
Thursday, April 25, 2024: 5:38PM - 7:00PM
Sheraton Times Square
Posted Room Name:
Central Park
Abstract No:
P0265
Submission Type:
Abstract Submission
Authors:
Sangyu Zhou (1), Xiaogang Sun (2), Yanxiang Liu (3)
Institutions:
(1) Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and, Beijing, NA, (2) Fuwai Hospital, Beijing, Xicheng Distric, (3) Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, Xicheng
Submitting Author:
Sangyu Zhou
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Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and
Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and
Co-Author(s):
Xiaogang Sun
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Fuwai Hospital
Fuwai Hospital
Yanxiang Liu
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Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Presenting Author:
Sangyu Zhou
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Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and
Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and
Abstract:
Preoperative Cardiac Troponin I Predicts Early Outcomes in Surgery for Acute Type A Aortic Dissection
Sangyu Zhou1, Yanxiang Liu1, Xiaogang Sun1
1Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Objective: To explore the association between preoperative cardiac troponin I (cTnI) and early outcomes in patients with acute type A aortic dissection (ATAAD).
Methods: The medical records of patients with ATAAD who underwent aortic surgery from April 2018 to December 2022 were retrospectively reviewed. Logistic regression analysis and linear regression analysis were performed to determine the association between cTnI and early outcomes. Receiver-operating characteristic (ROC) curve was performed to estimate the cut-off value of cTnI in the prediction of adverse events.
Results: A total of 535 patients were enrolled, of whom 163 (30.5%) had elevated cTnI. Primary endpoint of in-hospital mortality was 6 (3.7%) for the cTnI-positive group and 5 (1.3%) for the cTnI-negative group. The cTnI-positive group had a higher incidence of concomitant coronary artery bypass grafting and postoperative acute kidney injury Grade Ⅲ, and underwent longer time of cardiopulmonary bypass, aortic cross-clamp time, and intensive care unit (ICU) stay. Multivariate logistic regression analysis identified that preoperative cTnI was an independent risk factor of in-hospital mortality. ROC curve revealed that the cut-off value of cTnI in predicting in-hospital mortality was 0.28 ng/mL. Multivariate linear regression analysis showed that preoperative cTnI was also significantly associated with ICU stay.
Conclusions: Preoperative cTnI was a robust risk predictor of in-hospital mortality in patients with ATAAD undergoing aortic surgery and the cut-off value was 0.28 ng/mL. It was also strongly associated with ICU stay. Preoperative cTnI helped identify patients with high risk and provided information about prognosis.
Sangyu Zhou1, Yanxiang Liu1, Xiaogang Sun1
1Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Objective: To explore the association between preoperative cardiac troponin I (cTnI) and early outcomes in patients with acute type A aortic dissection (ATAAD).
Methods: The medical records of patients with ATAAD who underwent aortic surgery from April 2018 to December 2022 were retrospectively reviewed. Logistic regression analysis and linear regression analysis were performed to determine the association between cTnI and early outcomes. Receiver-operating characteristic (ROC) curve was performed to estimate the cut-off value of cTnI in the prediction of adverse events.
Results: A total of 535 patients were enrolled, of whom 163 (30.5%) had elevated cTnI. Primary endpoint of in-hospital mortality was 6 (3.7%) for the cTnI-positive group and 5 (1.3%) for the cTnI-negative group. The cTnI-positive group had a higher incidence of concomitant coronary artery bypass grafting and postoperative acute kidney injury Grade Ⅲ, and underwent longer time of cardiopulmonary bypass, aortic cross-clamp time, and intensive care unit (ICU) stay. Multivariate logistic regression analysis identified that preoperative cTnI was an independent risk factor of in-hospital mortality. ROC curve revealed that the cut-off value of cTnI in predicting in-hospital mortality was 0.28 ng/mL. Multivariate linear regression analysis showed that preoperative cTnI was also significantly associated with ICU stay.
Conclusions: Preoperative cTnI was a robust risk predictor of in-hospital mortality in patients with ATAAD undergoing aortic surgery and the cut-off value was 0.28 ng/mL. It was also strongly associated with ICU stay. Preoperative cTnI helped identify patients with high risk and provided information about prognosis.
Aortic Symposium:
Dissection
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