Outcomes of Cardiovascular Surgery in Women with Turner Syndrome

P0241 

Abstract Submission 

Lucas Ribe (1), Yuki Ikeno (1), Rana Afifi (2), Akiko Tanaka (3), Ferial Shihadeh (4), Anthony Estrera (3), Siddharth Prakash (5)

(1) McGovern Medical School at UTHealth, Houston, TX, (2) Memorial Hermann, Houston, TX, (3) Memorial Hermann Heart and Vascular Institute, Houston, TX, (4) McGovern Medical School UTHealth, Houston, TX, (5) N/A, Houston, TX

Lucas Ribe    -  Contact Me
McGovern Medical School at UTHealth

Yuki Ikeno    -  Contact Me
McGovern Medical School at UTHealth

Rana Afifi    -  Contact Me
Memorial Hermann

Akiko Tanaka    -  Contact Me
Memorial Hermann Heart and Vascular Institute

Ferial Shihadeh    -  Contact Me
McGovern Medical School UTHealth

*Anthony Estrera    -  Contact Me
Memorial Hermann Heart and Vascular Institute

Siddharth Prakash    -  Contact Me
N/A

Lucas Ribe    -  Contact Me
McGovern Medical School at UTHealth

Objective:

To describe short- and mid-term surgical outcomes of patients with Turner syndrome (TS) after cardiovascular interventions.

Methods:

All individuals aged 18 years or older at the time of surgical repair for cardiovascular diseases, including coarctation repairs, aortic disease and aortic dissection, between 2002 and 2022 were eligible. The primary endpoint focused on complications or death within 30 days of surgery. Secondary outcomes encompassed late complications within 6 months. The analysis incorporated data from the University of Texas Health Science Center at Houston and the Turner Syndrome Society of the United States.

Results:

We identified 22 patients who met the inclusion criterion. The median age was 46 years (range, 21-75). The most common medical condition was hypertension (77%), followed by hypothyroidism (59%). The most frequent indication for surgery was aortic root or ascending aortic aneurysms (68%), followed by symptomatic aortic stenosis in patients with bicuspid aortic valve (64%), coarctation of aorta (45%), and acute aortic dissection (18%). Respiratory complications were the most common (68%). Pleural effusions were the most frequent found sign on imaging studies (68%). Thoracentesis, or chest tube placement, was required in 33% (5/15).

Conclusions:

Patients with TS may be at an increased risk for postoperative complications after aortic surgery. Bicuspid aortic valve (59%) and coarctation of the aorta (45%) were the most common congenital malformations among our study group. Our study showed that respiratory complications were the most common, with thoracentesis or chest tube placement required in 33% of patients. This is the largest series presenting mid-term outcomes of adult-only Turner syndrome patients following aortic surgery repair.

Genetics of Aortic Disease