Ex vivo mechanical properties of aortic wall in acute dissection compared to non-dissected aorta
Presented During:
Thursday, April 25, 2024: 5:38PM - 7:00PM
Sheraton Times Square
Posted Room Name:
Central Park
Abstract No:
P0129
Submission Type:
Abstract Submission
Authors:
Pasquale Totaro (1), Ferdinando Auricchio (2), Simone Morganti (2), Stefano Pelenghi (1)
Institutions:
(1) IRCCS Foundation Hospital San Matteo, Pavia, PV, (2) University of Pavia, Pavia, PV
Submitting Author:
Pasquale Totaro
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IRCCS Foundation Hospital San Matteo
IRCCS Foundation Hospital San Matteo
Co-Author(s):
Ferdinando Auricchio
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University of Pavia
University of Pavia
Simone Morganti
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University of Pavia
University of Pavia
Stefano Pelenghi
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IRCCS Foundation Hospital San Matteo
IRCCS Foundation Hospital San Matteo
Presenting Author:
Pasquale Totaro
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IRCCS Foundation Hospital "San Matteo"-Pavia-Italy
IRCCS Foundation Hospital "San Matteo"-Pavia-Italy
Abstract:
Background
Acute aortic syndrome is a catastrophic event still characterized by high mortality even in case of successful prompt surgical treatment. Many authors evaluated biomechanical properties of aortic wall from "ex vivo" specimens in order to better clarify the physiopathology of aortic diseases and identify potential predictor risk factors for acute aortic complications. Significant limitation, so far, has been the lack of a "control group", being the majority of specimens harvested during scheduled aortic surgery. In this study we report our extensive experience in evaluation of biomechanical properties of aortic wall including specimens from patients experiencing acute aortic dissection and patients without aortic diseases
Materials and Methods
Aortic wall specimens were obtained in 113 patients who underwent ascending aorta replacement for chronic aortic aneurysm (NDAA: 73pts-64%), genetic aortic disease (GEN: 9pts–8%), acute aortic dissection (AAD: 11pts-10%) or heart transplantation (CG: 20pts- 17%). Mechanical uniaxial tensile ultimate stress test were performed on the fresh "ex vivo" sample within 24 hours from the harvesting measuring 3 parameters: Peek strain (Pstr: marker of aortic wall elasticity); Peek Stress (PS:marker of aortic wall strength) and Maximum elastic modulus (MEM: marker of aortic wall stiffness or resistance to deformation).
Results
Comparative analysis of overall mechnaical properties showed no significant differences between non dissected and dissected aorta. Control group, on other hands showed more preserved elasticity and strength (Fig 1A). Preserved mechanical properties of aortic wall in acute dissection compared to non-dissected disease was confirmed regardless aortic region and direction of mechanical stress (Fig 1B). Both Elasticity and Strenght of aortic wall were overall improved in specimens from control group (red square) especially in posterior wall (Fig 1C).
Conclusions
Our study on mechanical properties included patients with acute dissection and a control group without aortic dilatation. Control group showed indeed the better elasticity and strength of aortic wall thus confirming that impaired mechanical properties are characteristics of dilated aorta. Preserved mechanical properties in undamaged wall of dissected patients showed, however, that acute dissection is characterized by a focal fragility more than a diffuse impaired mechanical properties of aortic wall.
Acute aortic syndrome is a catastrophic event still characterized by high mortality even in case of successful prompt surgical treatment. Many authors evaluated biomechanical properties of aortic wall from "ex vivo" specimens in order to better clarify the physiopathology of aortic diseases and identify potential predictor risk factors for acute aortic complications. Significant limitation, so far, has been the lack of a "control group", being the majority of specimens harvested during scheduled aortic surgery. In this study we report our extensive experience in evaluation of biomechanical properties of aortic wall including specimens from patients experiencing acute aortic dissection and patients without aortic diseases
Materials and Methods
Aortic wall specimens were obtained in 113 patients who underwent ascending aorta replacement for chronic aortic aneurysm (NDAA: 73pts-64%), genetic aortic disease (GEN: 9pts–8%), acute aortic dissection (AAD: 11pts-10%) or heart transplantation (CG: 20pts- 17%). Mechanical uniaxial tensile ultimate stress test were performed on the fresh "ex vivo" sample within 24 hours from the harvesting measuring 3 parameters: Peek strain (Pstr: marker of aortic wall elasticity); Peek Stress (PS:marker of aortic wall strength) and Maximum elastic modulus (MEM: marker of aortic wall stiffness or resistance to deformation).
Results
Comparative analysis of overall mechnaical properties showed no significant differences between non dissected and dissected aorta. Control group, on other hands showed more preserved elasticity and strength (Fig 1A). Preserved mechanical properties of aortic wall in acute dissection compared to non-dissected disease was confirmed regardless aortic region and direction of mechanical stress (Fig 1B). Both Elasticity and Strenght of aortic wall were overall improved in specimens from control group (red square) especially in posterior wall (Fig 1C).
Conclusions
Our study on mechanical properties included patients with acute dissection and a control group without aortic dilatation. Control group showed indeed the better elasticity and strength of aortic wall thus confirming that impaired mechanical properties are characteristics of dilated aorta. Preserved mechanical properties in undamaged wall of dissected patients showed, however, that acute dissection is characterized by a focal fragility more than a diffuse impaired mechanical properties of aortic wall.
Aortic Symposium:
Dissection
Image or Table
