The Impact of Birth Weight and Gestational Age on Neo-Aortic Root Dilation in Post Arterial Switch Patients

P0336 

Abstract Submission 

Matthew Purlee (1), Lindsey Brinkley (2), John-Anthony Coppola (1), Mark Bleiweis (3), Jeffrey Jacobs (4), Giles Peek (5), Dalia Lopez-Colon (1), Dipankar Gupta (1)

(1) University of Florida, Gainesville, FL, (2) The University of Florida, N/A, (3) Shands Hospital, Gainesville, FL, (4) University of Florida Shands, Saint Petersburg, FL, (5) Congenital Heart Center, University of Florida, Gainesville, FL

Matthew Purlee    -  Contact Me
University of Florida

Lindsey Brinkley    -  Contact Me
The University of Florida

John-Anthony Coppola    -  Contact Me
University of Florida

*Mark Bleiweis    -  Contact Me
Shands Hospital

*Jeffrey Jacobs    -  Contact Me
University of Florida Shands

Giles Peek    -  Contact Me
Congenital Heart Center, University of Florida

Dalia Lopez-Colon    -  Contact Me
University of Florida

Dipankar Gupta    -  Contact Me
University of Florida

Matthew Purlee    -  Contact Me
University of Florida

Objective: To determine the impact of multiple factors including birth weight and gestational age on neo-aortic root dilation in patients with transposition of the great arteries that underwent an arterial switch operation.
Methods: A retrospective review of electronic medical records was conducted to identify patients who underwent an arterial switch operation (ASO) at our center from March 2002 to July 2023. Data collected included demographic data, operative data, mortality, and longitudinal echocardiography follow up neo-aortic root measurements. Neo-aortic root diameter growth rate for the first year post-operatively was calculated for each patient by calculating the difference in root diameter between the first post-op echo and the echo closest to one year of age and dividing by the time period between the two echocardiograms (cm/year). Correlations between neo-aortic root growth rate and additional variables were performed and analyzed for statistical significance.
Results: During the study period 98 patients underwent ASO at our center. Of these, 42 met inclusion criteria, while others were excluded due to inadequate follow up echo data or severely delayed ASO performed at greater than 1 month of life. Demographic data for patients as well as the results of multivariate analysis is summarized in table 1. Birth weight and gestational age in isolation did not demonstrate correlation with neo-aortic root growth rate. However, when analyzed in tandem on a multiple linear regression model, birth weight and gestational age had a statistically significant correlation with neo-aortic root growth rate in the first year of life, with coefficients of 0.93 and -0.22 respectively.
Conclusions: In summary, birth weight and growth rate are directly correlated, while gestational age and growth rate are inversely correlated with neo-aortic root growth rate in the first year of life in patients with transposition of the great arteries status post arterial switch operation. Further studies are required to better understand the mechanism responsible for these correlations and to correlate the neo-aortic root growth rate in the first year of life and its impact on long term outcomes after arterial switch operation.

Aortic Root