276. Concomitant Electromagnetic Navigation Transbronchial Microwave Ablation of Multiple Lung Nodules is Safe

*Michael Lanuti Invited Discussant
Harvard University
Boston, MA 
United States
 - Contact Me

After receiving a Bachelor of Science in Bioengineering from the University of Pennsylvania, Dr. Lanuti received his M.D. degree from the University of Pennsylvania School of Medicine. He completed his internship and residency in Surgery at the Hospital of the University of Pennsylvania and a two year research fellowship in a Thoracic Oncology Laboratory focusing on novel treatments (gene therapy) for lung cancer. He completed a Cardiothoracic Fellowship at the Massachusetts General Hospital. He has been on staff in the Division of Thoracic Surgery since 2004, and holds a parallel appointment as Associate Professor of Surgery at Harvard Medical School. He has been the Friedman-Lambert Scholar in Academic Thoracic Surgery at MGH/HMS since 2004.  He is the Director of Thoracic Oncology for the Division of Thoracic Surgery and the Thoracic Surgery liaison to the MGH Cancer Center.  Clinical interests include minimally invasive surgery for lung cancer, complex airway tumors, multimodality treatment of esophageal cancer, mediastinal tumors,  thermal ablation of lung tumors. 

Joyce Chan Abstract Presenter
Prince of Wales Hospital
Hong Kong  - Contact Me

Dr Joyce Chan is a resident at Division of Cardiothoracic Surgery in Prince of Wales Hospital, the Chinese University of Hong Kong. She graduated from the University of Hong Kong in 2015 with MBBS (1st Class Honours). Her main interest is in minimally invasive thoracic surgery, including single port VATS and electromegnetic navigation bronchoscopy (ENB) procedures. Prince of Wales Hospital is one of the pioneers in Asia in ENB biopsy and ablation of lung lesions, and is in keen development of robotic ENB procedures.


Monday, May 8, 2023: 4:45 PM - 5:00 PM
15 Minutes 
Los Angeles Convention Center 
Room: 408B 


Transbronchial microwave ablation of lung nodules using electromagnetic navigation bronchoscopy (ENB) is an emerging local therapy for lung oligometastases and early lung cancers in unfit patients. In particular, it is useful for the management of multifocal lung cancers as part of lung preserving strategy, as this population has become increasingly prevalent. Concomitant ablation of multiple lung nodules in a single operating session is postulated to provide a one-stop solution for this subgroup of patients.

Out of 72 patients who underwent ENB microwave ablation in hybrid operating room from April 2020 to October 2022, 18 patients had two or more lung nodules ablated in the same operating session. Nodules were proven or highly suspicious of malignancies or metastases. Feasibility and safety of concomitant ablation were retrospectively reviewed.

A total of 42 nodules in 18 patients (5 males and 13 females) underwent concomitant multi-nodular ablation, with a mean age of 63. Reasons for lung preserving strategy were multifocal lung cancer (83.3%) and lung oligometastases (16.7%). Among those with multifocal disease, 86.7% had previous major lung resection for lung cancer. Majority of patients had ablation to two lung nodules, while 2 had ablation to three nodules and another 2 had ablation to 4 lung nodules. 9 patients had ablation to lesions resided in the same lobe, 7 in different lobes on the same side, and 2 on both sides of lung. Mean nodule size is 9.9mm (range 5-20mm). Mean minimal margin was 5.9mm, while 24 nodules (57.1%) required double ablation to ensure good coverage. Patients undergoing concomitant ablation as opposed to separate sessions benefit from fewer general anesthesia risks, and the approximated time saved for intubation, ENB registration and verification is 30 minutes per patient. The average operating time was 196 minutes for double nodule ablation, while that for single nodule ablation was 126 minutes in our historical cohort. There were no major complications despite overlapping ablation zones and mean hospital stay was 1.19 days. Only 1 patient who had triple nodule ablation developed post-ablation reaction.

Concomitant transbronchial microwave ablation of multiple lung nodules is feasible and safe without increased complication rate. It is an important armamentarium in the contemporary lung preserving strategy for battling multifocal lung cancer or lung oligometastases.

Presentation Duration

7 minute presentation; 7 minute discussion 

View Submission