P115. Early and Long-Term Survival in Patients with Acute Kidney Injury after Acute Type A Aortic Dissection
Presented During: POD Abstracts (Available for viewing in the exhibit hall for the duration of the meeting)
Suwa red cross hospital
Matsumoto
Japan - Contact Me
Apr 2020– 　Department of Cardiovascular Surgery, Shinshu University School of Medicine, Matsumoto, Japan
2012 – 2018 PhD in Medical Science, Graduate School of Medicine, Shinshu University
2001 – 2007 BS in Medicine, Shinshu University
Thursday, April 25, 2024: 5:38 PM - 7:00 PM
Sheraton Times Square
Room: Central Park
Description
Objective:
The overall incidence of acute kidney injury (AKI) after aortic surgery is well documented, but its impact on the outcome of acute type A aortic dissection (ATAAD) has not been thoroughly investigated.
The aim of this study was to determine the significance of AKI in predicting postoperative morbidity and mortality in ATAAD patients.
Methods:
We performed a retrospective review of a prospectively collected database including 520 patients who underwent aortic surgery for TA-AAD from September 2004 to February 2023. AKI was classified according to the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines. We used a risk-adjusted Cox proportional hazards regression model to assess long-term survival.
Results:
Of 520 patients, 270 (51.9%) were diagnosed with AKI. The in-hospital mortality rates of AKI and non-AKI patients were significantly different (11.5% vs. 2.0%, respectively; P < 0.0001). Major risk factors for the development of AKI include male gender, visceral malperfusion, extended duration of cardiopulmonary bypass, and lower body temperature. Mean follow-up period was 51.3 ± 44.2 months. Long-term survival was significantly lower in patients with AKI (75.5% vs. 83.3% at 5 years, P = 0.0003). The Cox proportional hazards model identified AKI as an independent risk factor for increased long-term mortality (hazard ratio 1.61, P=0.04).
Conclusions:
Following surgery for acute aortic dissection, the development of acute kidney injury significantly increases the risk of in-hospital death and is an indicator of poor long-term prognosis.
Authors
Toshihito Gomibuchi (1), Tatsuichiro Seto (1)
Institutions
(1) Shinshu University, Matsumoto, Japan
The overall incidence of acute kidney injury (AKI) after aortic surgery is well documented, but its impact on the outcome of acute type A aortic dissection (ATAAD) has not been thoroughly investigated.
The aim of this study was to determine the significance of AKI in predicting postoperative morbidity and mortality in ATAAD patients.
Methods:
We performed a retrospective review of a prospectively collected database including 520 patients who underwent aortic surgery for TA-AAD from September 2004 to February 2023. AKI was classified according to the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines. We used a risk-adjusted Cox proportional hazards regression model to assess long-term survival.
Results:
Of 520 patients, 270 (51.9%) were diagnosed with AKI. The in-hospital mortality rates of AKI and non-AKI patients were significantly different (11.5% vs. 2.0%, respectively; P < 0.0001). Major risk factors for the development of AKI include male gender, visceral malperfusion, extended duration of cardiopulmonary bypass, and lower body temperature. Mean follow-up period was 51.3 ± 44.2 months. Long-term survival was significantly lower in patients with AKI (75.5% vs. 83.3% at 5 years, P = 0.0003). The Cox proportional hazards model identified AKI as an independent risk factor for increased long-term mortality (hazard ratio 1.61, P=0.04).
Conclusions:
Following surgery for acute aortic dissection, the development of acute kidney injury significantly increases the risk of in-hospital death and is an indicator of poor long-term prognosis.
Authors
Toshihito Gomibuchi (1), Tatsuichiro Seto (1)
Institutions
(1) Shinshu University, Matsumoto, Japan
Presentation Duration
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