171. Long-term Outcome of Patients with Peripheral Ground Glass Opacity Dominant Lung Cancer After Sublobar Resections: Final Report of JCOG0804/WJOG4507L
Memorial Sloan Kettering Cancer Center
New York, NY
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Biography: David R. Jones, MD
Dr. Jones graduated Phi Beta Kappa from West Virginia University and received his medical degree from West Virginia University School of Medicine where he was AOA. He completed his Thoracic Surgery Residency at the University of North Carolina at Chapel Hill, NC. In 1999, Dr. Jones joined the faculty at the University of Virginia where he became Professor and Vice-Chairman of the Department. In 2013 Dr. Jones was recruited to Memorial Sloan Kettering Cancer Center as Chief of Thoracic Surgery.
Dr. Jones is Professor & Chief of Thoracic Surgery and Executive Vice-chair of the Department of Surgery at MSKCC. He is also the Co-Director of the Fiona and Stanly Druckenmiller Center for Lung Cancer Research. He is the current Secretary of the AATS and Chair of the AATS-MSKCC Thoracic Surgery Oncology Group (TSOG) for clinical trials. Dr. Jones is Associate Editor for the Journal of Thoracic and Cardiovascular Surgery. He is recent past Chair of the NIH/NCI Tumor Progression and Metastasis (TPM) study section and currently serves on the NCI Board of Scientific Advisors. He serves on numerous national and international committees related to thoracic surgical research and clinical care.
Dr. Jones’s research focuses on mechanisms and drivers of metastases in lung cancer. His research has been funded by the NIH/NCI, Department of Defense, and the AACR. He has been the Principal Investigator or Co-PI on over 35 funded grants and currently holds 2 R01 awards from the NCI. He has published over 380 papers and has written over 35 book chapters. He was an early adopter of VATS anatomic resections and minimally-invasive esophagectomies and performs the majority of his operations using these minimally-invasive approaches.
Kumamoto University
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1989 Chiba University Hospital Pulmonary Surgery
1990 Department of Anesthesiology, Chiba University Hospital, Department of Intensive Care, Chiba Emergency Medical Center
1991 Odawara City Hospital Surgery
1993 Chiba University Hospital Pulmonary Surgery
1994 Department of Respiratory Medicine, Chiba Cancer Center
1995 Department of Pulmonary Surgery, Chiba University Hospital
1997 Department of Respiratory Medicine, Chiba Cancer Center
1998 Department of Thoracic Surgery, Omiya Red Cross Hospital
1999 Chiba University Hospital Pulmonary Surgery Assistant
2001 Postdoctoral fellow (University of Texas, USA)
2003 Chief Medical Officer, Department of Respiratory Medicine, Chiba Cancer Center
2005 Chiba University Hospital Respiratory Surgery Assistant 2008 Lecturer, Respiratory Surgery, Chiba University Hospital
2010 Professor, Department of Thoracic Surgery, Graduate School of Life Sciences, Kumamoto University
2021-Present Professor, Department of Respiratory Surgery and Breast Surgery, Graduate School of Life Sciences, Kumamoto University
Abstract
Methods. Between May 2009 and April 2011, 333 patients were enrolled from 51 institutions in Japan (median age was 62 at registration) and followed up until May 6, 2021. Of them, sublobar resections were performed in 314 patients (258 wedge resections and 56 segmentectomies), conversion lobectomies were performed in 11 patients, and 8 were ineligible. As an interventional surgical method, wedge resection is performed, and segmentectomy is permitted if the surgical margin is insufficient. The Median follow-up period at the final data cutoff point was 10.1 years.
Results. The 10-year RFS and OS for the 314 patients with sublobar resections were 98.6 % (95% CI, 96.2 – 99·5%) and 98.5% (95% CI, 96.1 – 99.4%), respectively. There was one local recurrence at resection margin. Among the patients, secondary cancers were observed in 43 patients (13.7%: 95% CI, 10.1 -18.0%), of them 19 were secondary LCs (6.1%: 95% CI, 3.7-9.3%).
Conclusions. The long-term results from JCOG0804/WJOG4507L suggested that sublobar resection for peripheral GGO dominant LC patients is a surgical procedure that can fully cured them. The indication of other treatment options would be further investigated.