P265. Preoperative Cardiac Troponin I Predicts Early Outcomes in Surgery for Acute Type A Aortic Dissection
Presented During: POD Abstracts (Available for viewing in the exhibit hall for the duration of the meeting)
Fuwai Hospital, Peking Union Medical College
Beijing, Beijing
China - Contact Me
PHD candidate in Department of Cardiovascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Thursday, April 25, 2024: 5:38 PM - 7:00 PM
Sheraton Times Square
Room: Central Park
Description
Preoperative Cardiac Troponin I Predicts Early Outcomes in Surgery for Acute Type A Aortic Dissection
Sangyu Zhou1, Yanxiang Liu1, Xiaogang Sun1
1Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Objective: To explore the association between preoperative cardiac troponin I (cTnI) and early outcomes in patients with acute type A aortic dissection (ATAAD).
Methods: The medical records of patients with ATAAD who underwent aortic surgery from April 2018 to December 2022 were retrospectively reviewed. Logistic regression analysis and linear regression analysis were performed to determine the association between cTnI and early outcomes. Receiver-operating characteristic (ROC) curve was performed to estimate the cut-off value of cTnI in the prediction of adverse events.
Results: A total of 535 patients were enrolled, of whom 163 (30.5%) had elevated cTnI. Primary endpoint of in-hospital mortality was 6 (3.7%) for the cTnI-positive group and 5 (1.3%) for the cTnI-negative group. The cTnI-positive group had a higher incidence of concomitant coronary artery bypass grafting and postoperative acute kidney injury Grade Ⅲ, and underwent longer time of cardiopulmonary bypass, aortic cross-clamp time, and intensive care unit (ICU) stay. Multivariate logistic regression analysis identified that preoperative cTnI was an independent risk factor of in-hospital mortality. ROC curve revealed that the cut-off value of cTnI in predicting in-hospital mortality was 0.28 ng/mL. Multivariate linear regression analysis showed that preoperative cTnI was also significantly associated with ICU stay.
Conclusions: Preoperative cTnI was a robust risk predictor of in-hospital mortality in patients with ATAAD undergoing aortic surgery and the cut-off value was 0.28 ng/mL. It was also strongly associated with ICU stay. Preoperative cTnI helped identify patients with high risk and provided information about prognosis.
Authors
Sangyu Zhou (1), Xiaogang Sun (2), Yanxiang Liu (3)
Institutions
(1) Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and, Beijing, NA, (2) Fuwai Hospital, Beijing, Xicheng Distric, (3) Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, Xicheng
Sangyu Zhou1, Yanxiang Liu1, Xiaogang Sun1
1Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Objective: To explore the association between preoperative cardiac troponin I (cTnI) and early outcomes in patients with acute type A aortic dissection (ATAAD).
Methods: The medical records of patients with ATAAD who underwent aortic surgery from April 2018 to December 2022 were retrospectively reviewed. Logistic regression analysis and linear regression analysis were performed to determine the association between cTnI and early outcomes. Receiver-operating characteristic (ROC) curve was performed to estimate the cut-off value of cTnI in the prediction of adverse events.
Results: A total of 535 patients were enrolled, of whom 163 (30.5%) had elevated cTnI. Primary endpoint of in-hospital mortality was 6 (3.7%) for the cTnI-positive group and 5 (1.3%) for the cTnI-negative group. The cTnI-positive group had a higher incidence of concomitant coronary artery bypass grafting and postoperative acute kidney injury Grade Ⅲ, and underwent longer time of cardiopulmonary bypass, aortic cross-clamp time, and intensive care unit (ICU) stay. Multivariate logistic regression analysis identified that preoperative cTnI was an independent risk factor of in-hospital mortality. ROC curve revealed that the cut-off value of cTnI in predicting in-hospital mortality was 0.28 ng/mL. Multivariate linear regression analysis showed that preoperative cTnI was also significantly associated with ICU stay.
Conclusions: Preoperative cTnI was a robust risk predictor of in-hospital mortality in patients with ATAAD undergoing aortic surgery and the cut-off value was 0.28 ng/mL. It was also strongly associated with ICU stay. Preoperative cTnI helped identify patients with high risk and provided information about prognosis.
Authors
Sangyu Zhou (1), Xiaogang Sun (2), Yanxiang Liu (3)
Institutions
(1) Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and, Beijing, NA, (2) Fuwai Hospital, Beijing, Xicheng Distric, (3) Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, Xicheng
Presentation Duration
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