P336. The Impact of Birth Weight and Gestational Age on Neo-Aortic Root Dilation in Post Arterial Switch Patients
Presented During: POD Abstracts (Available for viewing in the exhibit hall for the duration of the meeting)
University of Florida Shands Hospital
Gainesville, FL
United States - Contact Me
Matthew Purlee is a research assistant with the University of Florida Congenital Heart Center and an incoming first year medical student. Prior to his current role, he graduated with a Bachelor of Science in Chemistry cum laude from Mercer University. He is currently interested in cardiothoracic surgery as well as cardiology. Current research interests include congenital heart surgery, heart transplantation, and adult congenital heart disease.
Thursday, April 25, 2024: 5:38 PM - 7:00 PM
Sheraton Times Square
Room: Central Park
Description
Objective: To determine the impact of multiple factors including birth weight and gestational age on neo-aortic root dilation in patients with transposition of the great arteries that underwent an arterial switch operation.
Methods: A retrospective review of electronic medical records was conducted to identify patients who underwent an arterial switch operation (ASO) at our center from March 2002 to July 2023. Data collected included demographic data, operative data, mortality, and longitudinal echocardiography follow up neo-aortic root measurements. Neo-aortic root diameter growth rate for the first year post-operatively was calculated for each patient by calculating the difference in root diameter between the first post-op echo and the echo closest to one year of age and dividing by the time period between the two echocardiograms (cm/year). Correlations between neo-aortic root growth rate and additional variables were performed and analyzed for statistical significance.
Results: During the study period 98 patients underwent ASO at our center. Of these, 42 met inclusion criteria, while others were excluded due to inadequate follow up echo data or severely delayed ASO performed at greater than 1 month of life. Demographic data for patients as well as the results of multivariate analysis is summarized in table 1. Birth weight and gestational age in isolation did not demonstrate correlation with neo-aortic root growth rate. However, when analyzed in tandem on a multiple linear regression model, birth weight and gestational age had a statistically significant correlation with neo-aortic root growth rate in the first year of life, with coefficients of 0.93 and -0.22 respectively.
Conclusions: In summary, birth weight and growth rate are directly correlated, while gestational age and growth rate are inversely correlated with neo-aortic root growth rate in the first year of life in patients with transposition of the great arteries status post arterial switch operation. Further studies are required to better understand the mechanism responsible for these correlations and to correlate the neo-aortic root growth rate in the first year of life and its impact on long term outcomes after arterial switch operation.
Authors
Matthew Purlee (1), Lindsey Brinkley (2), John-Anthony Coppola (1), Mark Bleiweis (3), Jeffrey Jacobs (4), Giles Peek (5), Dalia Lopez-Colon (1), Dipankar Gupta (1)
Institutions
(1) University of Florida, Gainesville, FL, (2) The University of Florida, N/A, (3) Shands Hospital, Gainesville, FL, (4) University of Florida Shands, Saint Petersburg, FL, (5) Congenital Heart Center, University of Florida, Gainesville, FL
Methods: A retrospective review of electronic medical records was conducted to identify patients who underwent an arterial switch operation (ASO) at our center from March 2002 to July 2023. Data collected included demographic data, operative data, mortality, and longitudinal echocardiography follow up neo-aortic root measurements. Neo-aortic root diameter growth rate for the first year post-operatively was calculated for each patient by calculating the difference in root diameter between the first post-op echo and the echo closest to one year of age and dividing by the time period between the two echocardiograms (cm/year). Correlations between neo-aortic root growth rate and additional variables were performed and analyzed for statistical significance.
Results: During the study period 98 patients underwent ASO at our center. Of these, 42 met inclusion criteria, while others were excluded due to inadequate follow up echo data or severely delayed ASO performed at greater than 1 month of life. Demographic data for patients as well as the results of multivariate analysis is summarized in table 1. Birth weight and gestational age in isolation did not demonstrate correlation with neo-aortic root growth rate. However, when analyzed in tandem on a multiple linear regression model, birth weight and gestational age had a statistically significant correlation with neo-aortic root growth rate in the first year of life, with coefficients of 0.93 and -0.22 respectively.
Conclusions: In summary, birth weight and growth rate are directly correlated, while gestational age and growth rate are inversely correlated with neo-aortic root growth rate in the first year of life in patients with transposition of the great arteries status post arterial switch operation. Further studies are required to better understand the mechanism responsible for these correlations and to correlate the neo-aortic root growth rate in the first year of life and its impact on long term outcomes after arterial switch operation.
Authors
Matthew Purlee (1), Lindsey Brinkley (2), John-Anthony Coppola (1), Mark Bleiweis (3), Jeffrey Jacobs (4), Giles Peek (5), Dalia Lopez-Colon (1), Dipankar Gupta (1)
Institutions
(1) University of Florida, Gainesville, FL, (2) The University of Florida, N/A, (3) Shands Hospital, Gainesville, FL, (4) University of Florida Shands, Saint Petersburg, FL, (5) Congenital Heart Center, University of Florida, Gainesville, FL
Presentation Duration
PODS will be on display in the exhibit hall for the duration of the meeting during exhibit hall hours. PODS will also be available for viewing on the meeting website. There is no formal presentation associated with your POD, but we encourage you to visit the PODS area during breaks to connect with those viewing.